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Educating via Twitter – a ‘perfect platform’ for pathology

Educating via Twitter – a ‘perfect platform’ for pathology

Social media generally, and in particular platforms like Twitter, have been variously described as a bin fire, a sewer and a place for trolls. So why choose it as a platform for education?

Who bet­ter to ask than Dr Tris­tan Rut­land, NSW Health Pathol­o­gy anatom­i­cal pathol­o­gist, and the recent recip­i­ent of a pres­ti­gious US award for his self­less ded­i­ca­tion to pathol­o­gy education.

Dr Rut­land is also very pop­u­lar on Twit­ter. He’s no Elon Musk, but Tris­tan Rut­land (@TristanRutland7) has over 12,000 fol­low­ers and his use of the social net­work­ing plat­form to share and dis­cuss images of pathol­o­gy slides has attract­ed a devot­ed world­wide following.

The win­ner of the 2022 Col­lege of Amer­i­can Pathol­o­gists Res­i­dent Advo­cate Award and the 2020 Kon­rad Muller RCPA Out­stand­ing Teach­ing Award explained how the COVID pan­dem­ic fired his inter­est in what’s known as #PathTwit­ter – an inter­na­tion­al com­mu­ni­ty of pathol­o­gists shar­ing cas­es and edu­cat­ing each oth­er on how to avoid diag­nos­tic pitfalls.

“When the pan­dem­ic kicked off I end­ed up teach­ing our reg­is­trars via dig­i­tal, and that expand­ed to the point where I was teach­ing pret­ty much all the reg­is­trars in Aus­trala­sia in the RCP train­ing pro­gram every Sat­ur­day for four hours for six months,” Dr Rut­land explained.

“Then I had a cou­ple of them say­ing, ‘You should get involved in Twitter’.

“Now, social media has always been a bit of a bin fire, or a dump­ster fire, for me. It was always frus­trat­ing and peo­ple get­ting angry very quick­ly, so I just stayed clear of it. But then some­body intro­duced me to #PathTwit­ter and it’s just com­plete­ly the oppo­site of all that.

“Mar­ket­ing peo­ple would say, ‘it’s where the peo­ple are at’ – and it turns out Twit­ter is actu­al­ly one of the most per­fect plat­forms for pathology.

“You have to be suc­cinct, and you can show images, and that’s what peo­ple want.

“We’re busy peo­ple. Peo­ple can read what I post for two, three min­utes, and in a busy world it just seems to work.”

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Dr Rut­land has a the­o­ry about why the med­ical com­mu­ni­ty, and pathol­o­gists in par­tic­u­lar, seem to have avoid­ed the nas­ti­ness that has come to be syn­ony­mous with social media.

“We’re all doc­tors who already have a cer­tain lev­el of eth­i­cal behav­iour,” he said.

“Peo­ple who choose to engage on Twit­ter in this edu­ca­tion­al capac­i­ty tend to be sort of more dynam­ic, for­ward-think­ing and will prob­a­bly not want to engage in (nasty behav­iour), that’s not their forum.

“Peo­ple tend to be quite pro­fes­sion­al and very sup­port­ive. I also have patients and oth­er pro­fes­sion­als fol­low­ing me so I’m always very aware of my behaviour.”

Dr Rut­land is also very keen to empha­sise that the shar­ing of infor­ma­tion is done with­out any iden­ti­fi­ca­tion of patients.

tristan slide

He only shares images of cas­es that are years, if not decades old, to avoid any con­nec­tion to patients and it’s all de-identified.

“The whole idea is not to talk about the patient. It’s about dis­cussing the pit­falls and the things that are impor­tant for some­one to learn and make a diagnosis.

“What do you think this pos­si­bly could be? What are the pit­falls and how do you get around it, a bit of a dis­cus­sion about how you could avoid mak­ing this mis­take and poten­tial­ly do a dis­ser­vice for your patients.

“Par­tic­u­lar­ly with unique cas­es, then there’s a big, big, time lag. If some­thing is super rare, you would­n’t put it up the next day, you’d wait a year.”

As much as he enjoys pass­ing on his knowl­edge, Dr Rut­land says he’s also learned from oth­er peo­ple shar­ing their cases.

“I do it because I enjoy teach­ing and I also get some­thing out of review­ing my old­er cas­es, but I have to admit I have been saved and peo­ple in our depart­ment have been saved by stuff that peo­ple have put up on Twitter.

“I’ve actu­al­ly been like, ‘Yes, I’ve seen some­thing like this’, and it’s changed a diagnosis.”

More than that, the plat­form has changed the way he col­lab­o­rates with col­leagues around the world, open­ing up new oppor­tu­ni­ties for learn­ing and research.

“Absolute­ly. I’ve just got an abstract accept­ed for USCAP (Unit­ed States and Cana­di­an Acad­e­my of Pathol­o­gy), which is over in the US next year, and I’m one of about 60 pathol­o­gists that have nev­er met in per­son, haven’t had a zoom call – it was all through Twit­ter,” he said.

“There are peo­ple putting out calls for papers and col­lab­o­ra­tion on Twit­ter, for peo­ple to get involved in research arti­cles, to be involved in new projects and new ini­tia­tives. It’s com­plete­ly changed the way peo­ple collaborate.

“I had no idea this would actu­al­ly be such a pow­er­ful tool.”

He hopes the vis­i­bil­i­ty of the #PathTwit­ter com­mu­ni­ty will attract more peo­ple to pathol­o­gy, a spe­cial­ty strug­gling for num­bers worldwide.

“The irony is we are one of the most active med­ical com­mu­ni­ties on social media, yet it’s still very dif­fi­cult to attract peo­ple. We have trou­ble get­ting peo­ple into our train­ing cours­es and that’s a real shame.

“It’s fig­ur­ing out how to trans­late what we do here into, not nec­es­sar­i­ly engag­ing the gen­er­al pub­lic, but increased recog­ni­tion in the med­ical world.”

He acknowl­edges pathol­o­gy is not often viewed as a “sexy option” for med­ical stu­dents but insists that rep­u­ta­tion is not deserved.

“If I had my time again, I’d do pathol­o­gy again. It’s such a great spe­cial­ty because it’s super inter­est­ing. Peo­ple go, ‘You’re just look­ing at lit­tle glass slides’, but once you know what you’re look­ing at, it’s actu­al­ly real­ly engag­ing, one of the most engag­ing things I’ve done in my life.”

Genomic sequencing unlocks streamlined HIV care

In an Australian first, NSW Health Pathology is pioneering the use of whole genome sequencing to more efficiently match people living with HIV with the antiviral drugs most likely to slow or halt the progress of the potentially life-threatening disease.

The updat­ed assay devel­oped by Pro­fes­sor Sebas­ti­aan van Hal, a micro­bi­ol­o­gist cre­den­tialled in pathogen genomics at NSWHP’s Roy­al Prince Alfred lab, iden­ti­fies which par­tic­u­lar HIV strain the patient has and the strain’s like­ly response to every HIV antivi­ral drug on the market.

Armed with the results of this one pow­er­ful genom­ic test, doc­tors will know which antivi­ral drug will be most effec­tive in fight­ing the patient’s HIV infec­tion, and which med­ica­tions may do lit­tle to slow the virus’ progression.

The updat­ed assay, devel­oped with the assis­tance of NSW Health Pathol­o­gy sci­en­tists Thomas Le and Frances Jenk­ins, is a game chang­er in HIV treat­ment. It has effec­tive­ly future-proofed HIV antivi­ral resis­tance test­ing and giv­en clin­i­cians the infor­ma­tion they need to pro­vide more time­ly, tar­get­ed antivi­ral ther­a­py for Aus­tralians liv­ing with HIV.

Pro­fes­sor van Hal said he embarked on accred­i­ta­tion of the assay after spend­ing six months in Oxford, Eng­land learn­ing sequenc­ing analy­sis of pathogens.

“When I came home I saw an oppor­tu­ni­ty to put my new knowl­edge into prac­tice and stream­line what has tra­di­tion­al­ly been a cum­ber­some process for iden­ti­fy­ing antivi­ral resis­tance,” Prof van Hal said.

“It’s excit­ing to know this is an Aus­tralian first using whole genome sequenc­ing tech­nol­o­gy to test and report drug resis­tance in a virus.”

Pro­fes­sor van Hal explains the tech­nol­o­gy and method­ol­o­gy has come a long way since it came to Aus­tralia in the 1980s.

“In the ear­ly days, Sanger-based sequenc­ing test­ed just two of the virus’ genes for resis­tance against the very lim­it­ed num­ber of antivi­ral drugs on the mar­ket at that time,” Pro­fes­sor van Hal explained.

“As a whole new class of antivi­rals was devel­oped and intro­duced to the mar­ket, clin­i­cians turned to ad hoc, bespoke sequenc­ing to under­stand the virus’ resis­tance to them.”

The advent of new­er tech­nolo­gies, such as Next-Gen­er­a­tion Sequenc­ing (NGS), has rapid­ly advanced genomics. In the field of pathogen genomics, the val­ue of this tech­nol­o­gy was quick­ly realised with its appli­ca­tion for whole genome sequenc­ing of virus­es and bac­te­ria, includ­ing those resis­tant to first-line antibi­otics such as the life-threat­en­ing Staphy­lo­coc­cus and SARS-CoV­‑2.

Now, with Pro­fes­sor van Hal’s lead­er­ship, two years in val­i­da­tion, ver­i­fi­ca­tion against World Health Organ­i­sa­tion guide­lines and NATA accred­i­ta­tion, HIV has been added to the list.

Pro­fes­sor van Hal ran the first of what he pre­dicts will be a small but steady stream of requests in Octo­ber 2022.

Thank­ful­ly, the low inci­dence of HIV trans­mis­sion in Aus­tralia today, achieved through strong proac­tive pub­lic health efforts, means the assay will be a niche, but cru­cial, prod­uct in the pathol­o­gy landscape.

DNA breakthrough helps police trace ‘Beast of Bondi’

NSW Health Pathology’s Forensic and Analytical Science Service provided DNA results which assisted NSW police to track down the man known as the ‘Beast of Bondi’, responsible for a series of sexual assaults across Sydney’s eastern suburbs dating back to the 1980s.

When NSW Police con­firmed they had final­ly iden­ti­fied the ser­i­al sex offend­er known as the ‘Beast of Bon­di’ in Sep­tem­ber 2022, our team of foren­sic DNA experts in Syd­ney knew their work had helped solve a cold case span­ning four decades.

The male offend­er tar­get­ed women aged between 14 and 55, enter­ing their homes or abduct­ing them while they were out jog­ging or walking.

The cas­es were assigned to police Strike Force Doreen and includ­ed 31 attempt­ed and actu­al sex­u­al assault offences between 1985 and 2001.

“Strike Force Doreen has been with us for such a long time,” explains Car­ole Field, the DNA data­base man­ag­er at the Foren­sic and Ana­lyt­i­cal Sci­ence Ser­vice (FASS).

“The whole lab gets excit­ed when some­thing like this is solved.

“I always felt we were going to resolve these cas­es, but you just don’t know.”

Ini­tial­ly, attempts were made to match the man’s DNA pro­file across Aus­tralia and inter­na­tion­al­ly, but it wasn’t until advances in DNA tech­nol­o­gy that the foren­sic experts were able to iden­ti­fy a num­ber of men linked to the DNA pro­file of the offender.

The break­through came from a com­bi­na­tion of analysing famil­ial links from DNA sam­ples and tra­di­tion­al police work to trace the offender’s extend­ed fam­i­ly tree.

Foren­sic exam­i­na­tions, includ­ing addi­tion­al Y‑STR test­ing, revealed the DNA was linked to a man who died at the age of 66 ear­li­er this year.

In Sep­tem­ber 2022, it was con­firmed his DNA matched the sus­pect profile.

Over the years, media report­ing on the inci­dents referred to the sus­pect as ‘the Cen­ten­ni­al Park rapist’ (1980s), the Bon­di rapist (1990s), the track­suit rapist (2000) and ‘the Bon­di Beast’ (2016).

Ms Field said the close work­ing rela­tion­ship between the DNA experts at FASS and NSW Police con­tributes to suc­cess­ful outcomes.

“I think the inter­ac­tion between our teams was real­ly use­ful, and that has improved over time,” she said.

“We have a cold case coor­di­na­tor; Dr David Bruce and the police have a ded­i­cat­ed inves­ti­ga­tion team.

“We have a great rela­tion­ship, and we reg­u­lar­ly meet to dis­cuss not just this case, but many aspects of the sci­en­tif­ic DNA analy­sis and capabilities.”

Ms Field said as time goes on, the DNA data­base grows in size and will become an increas­ing­ly pow­er­ful tool to gen­er­ate DNA links and give police the infor­ma­tion they need to solve many oth­er cold cases.

Exploring AI’s powerful role in pathology

In Associate Professor Ewan Millar’s vision for the future of pathology in NSW, the skills, experience and expertise of Anatomical Pathologists is backed by powerful technology.

In the near future, Anatom­i­cal Pathol­o­gists – doc­tors who study body tis­sue and cells to diag­nose dis­eases like can­cer – will scru­ti­nise dig­i­tal slides rather than tra­di­tion­al glass slides to rou­tine­ly search for the small­est abnor­mal­i­ties in body tis­sue samples.

Ewan, a Senior Staff Spe­cial­ist Histopathol­o­gist with NSW Health Pathol­o­gy, based at St George Hos­pi­tal, believes it is like­ly Arti­fi­cial Intel­li­gence (AI) will take on the role of ‘Pathologist’s assis­tant’, pick­ing up on sub­tle pix­el pat­terns that flag tis­sue sam­ples for the doctor’s atten­tion and fur­ther inves­ti­ga­tion. Ulti­mate­ly, com­bin­ing the pathologist’s exper­tise and skill with advanced tech could rev­o­lu­tionise the diag­no­sis and under­stand­ing of dis­eases, and improve patient care and outcomes.

With enough devel­op­ment, the AI would also go one step fur­ther to iden­ti­fy bio­log­i­cal mark­ers, or ‘bio­mark­ers’, which indi­cate changes in tis­sue on a mol­e­c­u­lar lev­el, not vis­i­ble to the naked eye. These bio­mark­ers will not only help diag­nose dis­ease, such as can­cer, but help doc­tors under­stand a patient’s poten­tial response to tar­get­ed treatment.

It’s an ambi­tious vision, but one Ewan’s hap­py to chip away at thanks to a Researcher Exchange and Devel­op­ment with­in Indus­try (REDI) Fellowship.

Under the fel­low­ship, which aims to con­nect researchers with indus­try, Ewan is in the midst of a two-year, part-time project with Paige, a New York-based glob­al leader in Arti­fi­cial Intel­li­gence-based diag­nos­tic pathol­o­gy soft­ware. They mar­ket the first and only AI prod­uct to detect prostate can­cer approved by the US Food and Drug Admin­is­tra­tion (FDA). The AI is trained to iden­ti­fy sub­tle pix­el pat­terns in the tis­sue to accu­rate­ly pre­dict the pres­ence of prostate can­cer, and even map where in the prostate it is located.

Under the REDI Fel­low­ship, Ewan is assist­ing Paige to devel­op sim­i­lar AI prod­ucts for breast can­cer and breast can­cer lymph node spread. It is a dream role Ewan relishes.

“This REDI Fel­low­ship oppor­tu­ni­ty to work with Paige’s team of experts in AI is unri­valled,” Ewan said. “AI can real­ly trans­form the way pathol­o­gists work in the future, includ­ing right here in NSW.”

While the words ‘Arti­fi­cial Intel­li­gence’ can be anx­i­ety-induc­ing in med­ical cir­cles, Ewan explains AI is com­pli­men­ta­ry to tra­di­tion­al Anatom­i­cal Pathol­o­gy and will not replace human pathologists.

“It’s like hav­ing a sec­ond pair of eyes, or a good trainee pathol­o­gist by your side,” he explains.

“Pathol­o­gists can look at hun­dreds of slides a day. AI can run algo­rithms that dou­ble check the slides and can flag spe­cif­ic areas on the slides for the pathol­o­gist to con­cen­trate on. By mak­ing the work­flows more effi­cient, pathol­o­gists can con­cen­trate on the most mean­ing­ful parts of their role.”

While AI can over­come the chal­lenge of spot­ting abnor­mal­i­ties which are sim­ply too dif­fi­cult to detect with the naked eye, Ewan said it can also short-cut time-con­sum­ing, man­u­al tasks such as esti­mat­ing the loca­tion of small, dif­fi­cult to find tumours.

“Find­ing can­cer­ous tis­sue can be time-con­sum­ing,” Ewan admits. “Some work can be like look­ing for a nee­dle in a haystack, but the AI can be trained to recog­nise pix­el pat­terns. For exam­ple, pathol­o­gists may look at up to 75 slides from one patient’s prostate core biop­sies to find a tumour no more than 1mm in diam­e­ter. The AI is capa­ble of review­ing the slides with­in min­utes, com­pared to the time it takes to review slides manually.”

For now, Ewan is putting in the hard yards, train­ing the AI soft­ware to even­tu­al­ly give Anatom­i­cal Pathol­o­gists access to a pow­er­ful, accu­rate tool.

“We go through iter­a­tive cycles – train, test, review, work out what’s wrong, and repeat until the AI per­for­mance improves,” Ewan explains. “AI soft­ware must be close to 90 per cent accu­rate before it’s ready for fur­ther testing.”

While Ewan’s lend­ing his exper­tise to sev­er­al projects, most of his time is spent with the Bio­mark­er team devel­op­ing the next break­through in can­cer diagnostics.

From his home in Syd­ney, in the com­fort of his kids’ old gam­ing room, Ewan applies his pathol­o­gist eye to images used to train and val­i­date Paige’s bio­mark­er AI soft­ware. He reviews the dig­i­tal slides and the results that the AI algo­rithms pro­duce, then works close­ly with engi­neers to iden­ti­fy detec­tion errors and painstak­ing­ly improve the soft­ware per­for­mance slide by slide. Every can­cer type requires its own unique AI algo­rithm, which needs hun­dreds or thou­sands of slides to suc­cess­ful­ly train the software.

Using this same approach, Paige recent­ly built start-up algo­rithms capa­ble of detect­ing dig­i­tal bio­mark­ers for tumour muta­tions in breast and prostate can­cer. It’s hoped, in the future, dig­i­tal bio­mark­ers could be used to screen tumour slides for spe­cif­ic mol­e­c­u­lar fea­tures with­in just a few min­utes, to deter­mine a person’s response to tar­get­ed treat­ments. This new method for mon­i­tor­ing dis­ease tumour pro­gres­sion and treat­ment effi­ca­cy could poten­tial­ly replace some exist­ing expen­sive and time-con­sum­ing mol­e­c­u­lar tests.

The expe­ri­ence Ewan is gain­ing will pro­vide crit­i­cal knowl­edge to ensure dig­i­tal trans­for­ma­tion plan­ning, under­way at Anatom­i­cal Pathol­o­gy for NSW Health Pathol­o­gy, is AI-enabled for the future. It also pro­vides impor­tant indus­try expe­ri­ence to fur­ther sup­port his con­tri­bu­tion to AI researchers at UNSW Com­put­er Sci­ence and Engi­neer­ing, where sev­er­al PhD stu­dents are cur­rent­ly work­ing on breast can­cer pathol­o­gy AI projects.

Ewan’s REDI Fel­low­ship is sup­port­ed and fund­ed by MTP­Con­nect’s $32 mil­lion Researcher Exchange and Devel­op­ment with­in Indus­try (REDI) ini­tia­tive made pos­si­ble by the Med­ical Research Future Fund (MRFF), pro­vid­ing indus­try expe­ri­ences and skills devel­op­ment for ear­ly and mid-career researchers, clin­i­cians, and inno­va­tors to devel­op an indus­try ready work­force keep­ing pace with the demands of a rapid­ly chang­ing sector.

Hall of Fame for our Forensic Medicine Social Work service

Congratulations to our Forensic Medicine Social Work team in Newcastle who have been inducted into the University of Newcastle’s Work Integrated Learning Hall of Fame as part of the 2022 Employability Excellence Awards.

The Awards recog­nise organ­i­sa­tions such as NSW Health Pathol­o­gy that pro­vide pro­fes­sion­al prepa­ra­tion oppor­tu­ni­ties for stu­dents and sup­port the uni­ver­si­ty to pro­duce ‘life ready’ graduates.

Our Foren­sic Med­i­cine Social Work team has been work­ing close­ly with the uni­ver­si­ty since 2011, pro­vid­ing facil­i­tat­ed expe­ri­en­tial work­shops to all third and fourth year Social Work stu­dents as part of their field edu­ca­tion expe­ri­ence as well as host­ing stu­dents on placement.

Our team also pro­vides direct input into the devel­op­ment and deliv­ery of key areas of BSW (Hons) course con­tent such as grief and loss, the­o­ry and prac­tice, vio­lence and trau­ma, inter­per­son­al skills, group-work and organ­i­sa­tion­al practice.

“We have a strong com­mit­ment to help­ing devel­op social work grad­u­ates who are fit and ready for prac­tice in this chal­leng­ing, mean­ing­ful and life-chang­ing pro­fes­sion”, said Dan­ny Nugus, Senior Foren­sic Med­i­cine Social Worker.

“We have many Uni­ver­si­ty of New­cas­tle grad­u­ates employed at Foren­sic Med­i­cine New­cas­tle who also did their place­ment with us.”

“The major­i­ty of social work­ers employed at Foren­sic Med­i­cine New­cas­tle are Uni­ver­si­ty of New­cas­tle grad­u­ates, many of whom did a place­ment with us.”

“What sets these stu­dents apart is that the Bach­e­lor of Social Work pro­gram has both an expe­ri­en­tial learn­ing mod­el and an Hon­ours degree with a research com­po­nent that equips grad­u­ates with the aca­d­e­m­ic integri­ty, research eth­ic and trans­fer­able knowl­edge and skills that are inte­gral to effec­tive, eth­i­cal, safe and sus­tain­able social work prac­tice,” said Danny.

Well done to the team – we are grate­ful and proud of the impor­tant work you do to sup­port bereaved families.

Newcastle Forensic Medicine Social Work team
The New­cas­tle Foren­sic Med­i­cine Social Work team

Forbes, floods and going the extra mile

With the current flooding situation, we’re thinking of the Forbes community who are doing it tough right now. A special shout out to our resilient pathology staff at Forbes who are supporting their local communities and ensuring precious specimens reach our labs for testing.

Senior Super­vis­ing Sci­en­tist at NSW Health Pathology’s Forbes Lab Robyn Seber­ry said while Forbes Health Ser­vice (includ­ing the pathol­o­gy lab) is high on a hill, it’s more like an island with so much sur­round­ing water.

“It’s been chal­leng­ing for patients and our couri­ers to access the health ser­vice, and our thoughts are with every­one who have been affect­ed,” Robyn said.

“We’re send­ing a huge heart­felt thank you to our couri­ers who’ve been dri­ving in very chal­leng­ing cir­cum­stances over the past month.

“They’ve tak­en so many detours and dis­cov­ered many back roads and safe pas­sages to get around the flood­ed water­ways. They’re an awe­some crew and we are lucky to have them as part of our service.”

As well as our own couri­ers like Rus­sell Platt (pic­tured), we also had to call on help from local emer­gency services.

Thank you to the Rur­al Fire Ser­vice and SES vol­un­teers who came to our aid to fer­ry pre­cious spec­i­mens from out­ly­ing hos­pi­tals across the water to our lab in Forbes, and also ensured we got our send away spec­i­mens out to oth­er labs.

We’re so grate­ful to these teams for their sup­port, which has allowed us to con­tin­ue pro­vid­ing essen­tial pathol­o­gy ser­vices to our communities.

Robyn said Forbes is an incred­i­ble and resilient com­mu­ni­ty who are ral­ly­ing in very dif­fi­cult times.

“It’s been inspir­ing to be part of such a car­ing and resilient team who are look­ing out for each oth­er. The Forbes staff are all cur­rent­ly safe but we have fam­i­ly and friends that are impact­ed by this flood­ing and our thoughts are with our com­mu­ni­ty as they begin the dif­fi­cult task of clean­ing up,” Robyn said.

Courier pic scaled

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