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Development and implementation of an advanced toxicology screening method to include kava-related compounds

Finalist | Contributing to better health and justice systems Drugs and Driving Toxicology

On 11 Octo­ber 2019, it was announced that Kava impor­ta­tion laws were to be relaxed in a tri­al that aimed to strength­en cul­tur­al and eco­nom­ic ties with our Pacif­ic Island neigh­bours. More than two years lat­er, the com­mer­cial impor­ta­tion of Kava for use as a food was allowed.

Law enforce­ment agen­cies antic­i­pat­ed this would make the plant-derived anti­de­pres­sant drug more read­i­ly avail­able and there­fore more like­ly to impede dri­vers on our roads.

For our Foren­sic and Ana­lyt­i­cal Sci­ence Ser­vice (FASS) Drugs and Dri­ving Tox­i­col­o­gy Lab­o­ra­to­ry it was yet anoth­er new hur­dle in the ever-evolv­ing drug enforce­ment race.

The lab tests police sam­ples from dri­vers thought to be under the influ­ence of drugs and pro­vides crit­i­cal intel­li­gence for investigations.

The screen­ing method it used at the time could detect up to 82 drugs in blood and urine – but not Kava.

To respond to the changed leg­is­la­tion and keep the faith of police and jus­tice part­ners, the team had to act fast.

The thor­ough, time­ly devel­op­ment and val­i­da­tion pro­vid­ed a new way to screen for six Kava-relat­ed com­pounds and added anoth­er 24 drugs in response to polic­ing require­ments – a 34 per cent increase in scope.

The extrac­tion process was updat­ed in line with sci­en­tif­ic advances. Instru­ments were used to their full poten­tial deliv­er­ing a 200 per cent increase in through­put from decreased sam­ple prepa­ra­tion and run time.

All this was achieved in a chal­leng­ing time­frame with no impact on busi­ness-as-usu­al work or stake­hold­er priorities.

The team demon­strat­ed its will­ing­ness and abil­i­ty to inno­vate and con­tin­u­al­ly improve ser­vice to keep pace with our clients’ needs.

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